As you know, I have lived with cystic fibrosis (CF), a progressive, genetic disease that impacts nearly every part of my life, for 51 years. Thanks to remarkable advances in research, care, and the support of the incredible CF community, I have been able to live a full and meaningful life. I became a doctor, married my college sweetheart, have traveled many places throughout the world, and became a dad. I am the luckiest guy I know! But none of it has come easily. CF is a daily fight. My mornings begin hours earlier than most—starting with multiple breathing treatments and airway clearance, as well as handfuls of pills and various injections. On top of that, I manage the diabetes, digestive complications, and ongoing infections that come with this disease. I plan every part of my day around managing CF so that I can continue to do the things I love—and be present for the people I love.

While modulator therapies like Trikafta® have changed the lives of many, I'm among the 10% of people with CF who have rare mutations that don't respond to current modulators. And so, I continue to wait, work, and fight for better treatments.
This spring, I participated in an mRNA gene therapy clinical trial—an experience I never imagined I'd be part of, but one I embraced with hope and urgency. While we did not get the response for which we were hoping, at least we helped advance the
study of CF. I chose to participate for my family, friends, and for the thousands of others still waiting for a breakthrough. I did it because I believe in the science. And because I believe in the Cystic Fibrosis Foundation.

On November 1, 2025, I will serve as the Bid for a Cure speaker at the Wine & Roses Gala. I'll be sharing more about my experience in the trial, the burden of living with CF, and why—after everything—my belief in this mission has never wavered. It's an opportunity to speak honestly about what this fight looks like day to day and how close we are to turning the page in the best story in medicine for people like me.

At the Gala, we will be asking for your support through the auctions and the Bid for a Cure (the chance to give a tax-deductible monetary gift). Your gift—no matter the size—will help fund the research that could lead to the next breakthrough. It will help people like me hold on to hope. And it will ensure that future generations won't have to live with this disease the way I have. Amy and I hope that you'll join us at the Gala and support me as I share my story.

We would be honored to have you join us at the 2025 Wine & Roses Gala as a sponsor or guest. Sponsorship opportunities not only offer meaningful recognition but also provide critical support for the research that gives families like mine hope.

If you’d prefer to attend as an individual guest, you can request your tickets by visiting wineandrosesgala.com/tickets. If you are unable to attend the Gala this year, we would ask you to still consider supporting the mission financially again this year. On the back of this letter, you'll find details about how to support our 2025 Wine & Roses Gala fundraising efforts. If you're able to give, we'd be deeply grateful.

Because of you, we have made incredible progress toward treatment for all people with cystic fibrosis. This year's theme of the Gala is TOGETHER. Just imagine what we could do together.

With so much gratitude,
Chuck + Amy Fox